Growth differentiation factor 9:bone morphogenetic protein 15 (GDF9:BMP15) synergism and protein heterodimerization
نویسندگان
چکیده
منابع مشابه
Synergistic roles of bone morphogenetic protein 15 and growth differentiation factor 9 in ovarian function.
Knockout mouse technology has been used over the last decade to define the essential roles of ovarian-expressed genes and uncover genetic interactions. In particular, we have used this technology to study the function of multiple members of the transforming growth factor-beta superfamily including inhibins, activins, and growth differentiation factor 9 (GDF-9 or Gdf9). Knockout mice lacking GDF...
متن کاملBone morphogenetic protein 15 and growth differentiation factor 9 co-operate to regulate granulosa cell function.
The oocyte-secreted polypeptide growth factors, growth differentiation factor 9 (GDF9) and bone morphogenetic protein 15 (BMP15, also known as GDF9B) have both been shown to be essential for ovarian follicular growth and function. The effects of murine (m) and ovine (o) GDF9 as well as oBMP15, alone or together, on 3H-thymidine uptake and progesterone and inhibin production by granulosa cells f...
متن کاملGrowth differentiation factor 9:bone morphogenetic protein 15 heterodimers are potent regulators of ovarian functions.
The TGF-β superfamily is the largest family of secreted proteins in mammals, and members of the TGF-β family are involved in most developmental and physiological processes. Growth differentiation factor 9 (GDF9) and bone morphogenetic protein 15 (BMP15), oocyte-secreted paralogs of the TGF-β superfamily, have been shown genetically to control ovarian physiology. Although previous studies found ...
متن کاملBone morphogenetic protein and growth differentiation factor cytokine families and their protein antagonists.
The BMPs (bone morphogenetic proteins) and the GDFs (growth and differentiation factors) together form a single family of cystine-knot cytokines, sharing the characteristic fold of the TGFbeta (transforming growth factor-beta) superfamily. Besides the ability to induce bone formation, which gave the BMPs their name, the BMP/GDFs display morphogenetic activities in the development of a wide rang...
متن کاملSingle Nucleotide Polymorphism Analysis of the Bone Morphogenetic Protein Receptor IB and Growth and Differentiation Factor 9 Genes in Rayini Goats (Capra hircus)
The FecB, a mutation in the bone morphogenetic protein receptor IB (BMPR-IB) gene, which increases the fecundity of Booroola Merino sheep, and FecGH, a mutation in the Growth and Differentiation Factor 9 (GDF9), which affects the fecundity of Cambridge and Belclare sheep in a dose sensitive manner, were analyzed as candidate genes associated with the prolificacy in Rayini goats. These polymorph...
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ژورنال
عنوان ژورنال: Proceedings of the National Academy of Sciences
سال: 2013
ISSN: 0027-8424,1091-6490
DOI: 10.1073/pnas.1303459110